Samira Rathod attended the Sir J. J. College of Architecture in Mumbai and graduated in 1986. Thereafter, she received a Master in Architecture degree from the University of Illinois at Urbana-Champaign in 1988. Samira Rathod worked for the California firm of Don Wald and Associates on various projects including some for Clint Eastwood. Returning to India, she worked for Ratan Batliboi and then eventually started her own partnership firm in 1995 called RLC. Her 1996 solo furniture exhibition called 'Liasons de Formes led to a much broader public recognition in India. In 2000 she started a solo practice called Samira Rathod Design Associates. In 2008, she founded SPADE, a critical architectural publication with a focus on Indian architecture. Rathod is an adjunct faculty member at the Kamla Raheja Vidyanidhi Institute for Architecture and Environmental Studies (KRVIA) in Mumbai.